Immunogenetic Aspects Helicobacter Pylori Associated Gastroduodenal Pathology In Children

We investigated the associations between the host HLA-DQ variation and the prevalence of H ruli in the Indonesian population with an H. pylori-infected level of 11.2% in people living in the Bukhara region. It was noted that individuals carrying the DQB1 * 0401 genotypes are at significantly greater risk of developing H infection. .lori compared to individuals with the DQB1 0301 genotypes. The DQA1 or DQB1 haplotypes were not associated with H. pulori infection.


INTRODUCTION
Currently, chronic pathology of the stomach and duodenum in children and adolescents occupies a significant place in the structure of the overall morbidity [N. M. Zvyagina, O. V. Tetonov 2015]. The appeal of children to medical institutions for diseases of the digestive system does not reflect the true prevalence of this pathology. [Volkov A.I. 2012]. According to the results of the All-Russian dispensary examination, diseases of the digestive system rank second in the structure of childhood morbidity in adolescents. The incidence of chronic gastritis and chronic duodenitis in Russia is 300-400 The American Journal of Medical Sciences and Pharmaceutical Research (ISSN -2689(ISSN - -1026 Published: August 20, 2020  To study polymorphic variants of cytokine genes and their receptors in children with Helicobacter pylori associated gastroduodenal pathology.

MATERIAL AND METHODS
Peptic ulcer disease (PU) in childhood is no longer considered a rare disease and represents a serious problem in clinical medicine due to its high prevalence. Rejuvenation of pathology, chronic recurrent course, the possibility of life-threatening complications and a decrease in the effectiveness of treatment [1][2][3]. Despite the introduction of modern therapy regimens, over the past decade, the incidence of ulcer in schoolchildren has increased 2.5 times, the percentage of unsatisfactory results of inpatient treatment of patients has doubled, and the frequency of relapses has increased from 50 to 75%. The complication rate Currently, chronic pathology of the stomach and duodenum in children and adolescents occupies a significant place in the structure of overall morbidity [N. N1. Zvyagin. OV Antonov 2015 The turnover of children to medical institutions for diseases of the digestive system does not reflect the true prevalence of this pathology.
[nine]. According to the results of the All-Russian dispensary examination, diseases of the digestive system rank second in the structure of childhood morbidity in adolescents. The incidence of chronic gastritis and chronic duodenitis in Russia is 300-400 per 1000 child population [14]. and in the Tashkent region 200 per 1000 (10). According to the forecasts of experts from the World Health Organization (WHO), by the middle of the 21st century, diseases of the digestive system will occupy one of the leading places, due to the lifestyle of a modern person (stress, poor nutrition, physical inactivity, bad habits). environmental pollution, an increase in the proportion of low-quality and genetically modified food in the diet [13].
Helicobacter pylori (HP) infection is currently considered as the leading etiopathogenetic factor of peptic ulcer disease (PUD) and chronic gastritis (CG) in childhood. Studies carried out in Russia and Europe have shown that the HLA system plays a fundamental role in the formation of the clinical variant of N. pyor-associated gastroduodenal pathology and the clinical outcome of the disease (gastritis, gastroduodenal ulcer, ulcer, cancer, maltoma) [11]. The HLA genetic system is the most polymorphic human genetic system, which is explained by the biological role that HLA antigens play in maintaining the body's immunological homeostasis and protecting it from pathogens. The HLA gene complex is located on the short arm of chromosome 6 and includes a number of loci (A. B. C. DR. DQ. DP). The product of the HLA A. B. C loci is called class I antigens, and the HLA DR loci. DQ and DР -class II antigens.

RESULT AND DISCUSSION
The polymorphism of the HLA system is responsible for variations in the body's immune response to various antigens and predetermines the body's susceptibility or immunity to diseases, the occurrence of which is mediated by the immune system. Polymorphism is closely associated with ethnic factors, and therefore individuals which were expressed to varying degrees and were found in different combinations.

CONCLUSIONS
We investigated the associations between the HbA-Er Hoshin variation and the prevalence of H. pyori in a population with an H.py1ori level of 11.2 ** in people living in the Bukhara region. It was noted that persons carrying the genotypes 1X ^ B 1 * 0401. have a significantly higher risk of developing H. pyori infection compared with lipas with genotypes EX} B1 0301. Haplotypes 1X? A1 or OOB1 were not associated with H. pyori infection.