IMMUNOSUPPRESSIVE RESPECTS AND STRUCTURE OF ACTION OF Β-GLUCANS

Abstract

β-glucans are found in bacterial and fungal cellwalls and have been ensnared in the inception of against microbial immuneresponse. β-glucan sact onDectin-1, complementreceptor (CR3) and TLR-2/6 immunereceptors. They trigger a gathering of immune cell sincludingmacrophages, neutrophils, monocytes, natural killer cells and dendritic cells. Mostβ-glucansenter the proximalsmallintestine and some are caught by the macrophages. They are disguised and divided inside the cells, then transported by the macrophages to the marrow and endothelial reticular framework. The smallβ-glucansfragments are eventually released by the macrophages and taken up by other immune cells leading to various immune responses.